Methylene chloride exposure and carboxyhemoglobin levels in cabinetmakers

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Methylene chloride exposure and carboxyhemoglobin levels in cabinetmakers

Methylene chloride (MeCl(2)) is a clear colorless volatile sweet smelling lipophilic solvent used as a constituent of wood vanishes and paints. Human exposure is mainly due to inhalation and its biotransformation by the hepatic mixed function oxidases (MFO) leads to formation of carbon monoxide (CO). Simultaneous exposure to MeCl(2) and increased ambient CO results in undesirably increased carb...

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Application of physiologically based pharmacokinetic modeling in setting Acute Exposure Guideline Levels (AEGLs) for methylene chloride

Acute Exposure Guideline Levels (AEGLs) are derived to protect the human population from adverse health effects in case of single exposure due to an accidental release of chemicals into the atmosphere. AEGLs are set at three different levels of increasing toxicity for exposure durations ranging from 10 min to 8 hours. In the AEGL-setting for methylene chloride specific additional topics had to ...

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Application of physiologically based pharmacokinetic modeling in setting acute exposure guideline levels for methylene chloride.

Acute exposure guideline levels (AEGLs) are derived to protect the human population from adverse health effects in case of single exposure due to an accidental release of chemicals into the atmosphere. AEGLs are set at three different levels of increasing toxicity for exposure durations ranging from 10 min to 8 h. In the AEGL setting for methylene chloride, specific additional topics had to be ...

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Methylene chloride burns.

A young man was asked to clean out the residues of an acetate methylene chloride mixture from the sides and bottom of an open vessel some 3ft (1 m) in diameter and 3ft 6ins (1-2 m) deep. He was instructed to use a detergent, hot water, scrubbing brush, and a scraper for the job, but as he had seen the maintenance engineer cleaning the pipework of acetate residue with methylene chloride, he deci...

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Measurement of methylene chloride.

I read with great interest the paper ‘Characteristics of peaks of inhalation exposure to organic solvents’ (Preller et al., 2004). I noticed that the authors used the MiniRAE Plus Professional Photoionization Detector (PID) (RAE Systems USA) to measure the total organic solvents exposure. My company, Shawcity Ltd, has represented RAE Systems in the UK for 10 years, and we are therefore very fam...

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ژورنال

عنوان ژورنال: Indian Journal of Occupational and Environmental Medicine

سال: 2007

ISSN: 0019-5278

DOI: 10.4103/0019-5278.34529